Research Projects

Investigating the role of the T cell receptor (TCR) in ALCL pathogenesis towards the development of an innovative therapeutic approach

Masarykova Univerzita –  Faculty of Medicine 

Supervisor: Suzanne TURNER

Research objectives:

A defining feature of ALCL is the lack of 

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Validation of bypass mechanisms of resistance to ALK TKIs in ALCL

Masarykova Univerzita –  Faculty of Medicine

Supervisor: Šárka POSPÍŠILOVÁ

Research objectives:

ALK inhibitors have been slow to reach the clinic for children with ALK-expressing ALCL but experience of treating adults 

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Epigenetics of ALCL Drug Resistance

Medizinische Universität Wien 

Supervisor: Gerda EGGER

Research objectives: Our lab has previously identified DNA methylation signatures of primary human ALCL that reflect biological tumour characteristics and provide some insight into the potential origin of ALCL.

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The role of STAT1 activation and immunity in ALCL oncogenesis

Medizinische Universität Wien 

Supervisor: Olaf MERKEL

Research objectives:

The role of STAT1 has been understudied in ALCL because usually STAT1 is seen as an immunity-driven tumour suppressor. In
recent studies STAT1 has been shown to 

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Investigating the role of STAT5 in ALCL pathogenesis

Medizinische Universität Wien

Supervisor: Lukas KENNER

Research objectives: 

Preliminary data from our group demonstrates that deletion of platelet derived growth factor receptor beta (PDGFRβ), in a murine mimic of anaplastic

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Targeting CCR7-PI3Kg axis to eradicate persistent lymphoma cells in ALK+ ALCL

Università di Torino

Supervisor:                                                        Claudia VOENA, Roberto CHIARLE

Research objectives: 

To eradicate long-term persister cells by co-targeting of the CCR7-PI3Kγ axis. 

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Integration of clonal evolution and single-cell mutational and expression profiles in ALK+ ALCL

Università degli studi di Milano – BICCOCA

Supervisor:
Carlo GAMBACORTI-PASSERINI

We plan to run single-cell RNA (scRNA) sequencing to prospectively analyse the 

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Establishment of ALK-autoantibodies, T cell responses against ALK and cell-free DNA as biomarkers and for response monitoring of patients with ALCL

Universitätsklinikum Hamburg-Eppendorf

Supervisor: Wilhelm WOESSMANN, Christine DAMM-WELK

 

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Identification of New Biomarkers of Disease Resistance in ALCL of childhood: the role of exosomes.

Università degli studi di Padova

Supervisor: Lara MUSSOLIN

Research objectives:

Liquid biopsy analysis has grown exponentially in the last few years, 

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Development of a TME-based Immunoscore as a prognostic and predictive biomarker for ALCL

Universitätsklinikum Freiburg

Supervisor: Lena ILLERT

Research objectives:

This project aims to develop a TME (Tumour Microenvironment)-based biomarker for the prognosis and the 

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Investigating the diverse microenvironment of ALCL and its effects on the sub-clonal heterogeneity of tumours

Masarykova Univerzita –  Faculty of Medicine 

Supervisor: Suzanne TURNER

Research objectives:

A variety of -omics approaches will be used to examine the cellular landscape 

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