Investigating the role of the T cell receptor (TCR) in ALCL pathogenesis towards the development of an innovative therapeutic approach
Masarykova Univerzita – Faculty of Medicine
Supervisor: Suzanne TURNER
Research objectives:
A defining feature of ALCL is the lack of
Validation of bypass mechanisms of resistance to ALK TKIs in ALCL
Masarykova Univerzita – Faculty of Medicine
Supervisor: Šárka POSPÍŠILOVÁ
Research objectives:
ALK inhibitors have been slow to reach the clinic for children with ALK-expressing ALCL but experience of treating adults
Epigenetics of ALCL Drug Resistance
Medizinische Universität Wien
Supervisor: Gerda EGGER
Research objectives: Our lab has previously identified DNA methylation signatures of primary human ALCL that reflect biological tumour characteristics and provide some insight into the potential origin of ALCL.
The role of STAT1 activation and immunity in ALCL oncogenesis
Medizinische Universität Wien
Supervisor: Olaf MERKEL
Research objectives:
The role of STAT1 has been understudied in ALCL because usually STAT1 is seen as an immunity-driven tumour suppressor. In
recent studies STAT1 has been shown to
Investigating the role of STAT5 in ALCL pathogenesis
Medizinische Universität Wien
Supervisor: Lukas KENNER
Research objectives:
Preliminary data from our group demonstrates that deletion of platelet derived growth factor receptor beta (PDGFRβ), in a murine mimic of anaplastic
Targeting CCR7-PI3Kg axis to eradicate persistent lymphoma cells in ALK+ ALCL
Università di Torino
Supervisor: Claudia VOENA, Roberto CHIARLE
Research objectives:
To eradicate long-term persister cells by co-targeting of the CCR7-PI3Kγ axis.
Integration of clonal evolution and single-cell mutational and expression profiles in ALK+ ALCL
Università degli studi di Milano – BICCOCA
Supervisor:
Carlo GAMBACORTI-PASSERINI
We plan to run single-cell RNA (scRNA) sequencing to prospectively analyse the
Establishment of ALK-autoantibodies, T cell responses against ALK and cell-free DNA as biomarkers and for response monitoring of patients with ALCL
Universitätsklinikum Hamburg-Eppendorf
Supervisor: Wilhelm WOESSMANN, Christine DAMM-WELK
Identification of New Biomarkers of Disease Resistance in ALCL of childhood: the role of exosomes.
Università degli studi di Padova
Supervisor: Lara MUSSOLIN
Research objectives:
Liquid biopsy analysis has grown exponentially in the last few years,
Development of a TME-based Immunoscore as a prognostic and predictive biomarker for ALCL
Universitätsklinikum Freiburg
Supervisor: Lena ILLERT
Research objectives:
This project aims to develop a TME (Tumour Microenvironment)-based biomarker for the prognosis and the
Investigating the diverse microenvironment of ALCL and its effects on the sub-clonal heterogeneity of tumours
Masarykova Univerzita – Faculty of Medicine
Supervisor: Suzanne TURNER
Research objectives:
A variety of -omics approaches will be used to examine the cellular landscape